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Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review.
- Source :
-
British journal of anaesthesia [Br J Anaesth] 2019 Sep; Vol. 123 (3), pp. 335-349. Date of Electronic Publication: 2019 Jul 11. - Publication Year :
- 2019
-
Abstract
- Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute and chronic pain states, especially in acute postoperative and chronic neuropathic pain. These effects cannot be explained by its voltage-gated sodium channel blocking properties alone, but the responsible mechanisms are still elusive. This narrative review focuses on available experimental evidence of the molecular mechanisms by which systemic lidocaine exerts its clinically documented analgesic effects. These include effects on the peripheral nervous system and CNS, where lidocaine acts via silencing ectopic discharges, suppression of inflammatory processes, and modulation of inhibitory and excitatory neurotransmission. We highlight promising objectives for future research to further unravel these antinociceptive mechanisms, which subsequently may facilitate the development of new analgesic strategies and therapies for acute and chronic pain.<br /> (Copyright © 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Acute Pain metabolism
Analgesics therapeutic use
Anesthetics, Local therapeutic use
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Chronic Pain metabolism
Humans
Ion Channels drug effects
Lidocaine therapeutic use
Synaptic Transmission drug effects
Acute Pain drug therapy
Analgesics pharmacology
Anesthetics, Local pharmacology
Chronic Pain drug therapy
Lidocaine pharmacology
Molecular Targeted Therapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1471-6771
- Volume :
- 123
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- British journal of anaesthesia
- Publication Type :
- Academic Journal
- Accession number :
- 31303268
- Full Text :
- https://doi.org/10.1016/j.bja.2019.06.014