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17DD Yellow Fever Revaccination and Heightened Long-Term Immunity in Populations of Disease-Endemic Areas, Brazil.
- Source :
-
Emerging infectious diseases [Emerg Infect Dis] 2019 Aug; Vol. 25 (8), pp. 1511-1521. Date of Electronic Publication: 2019 Aug 17. - Publication Year :
- 2019
-
Abstract
- We evaluated the duration of neutralizing antibodies and the status of 17DD vaccine-specific T- and B-cell memory following primary and revaccination regimens for yellow fever (YF) in Brazil. We observed progressive decline of plaque-reduction neutralization test (PRNT) seropositivity and of the levels of effector memory CD4+ and CD8+ T cells, as well as interferon-γ+CD8+ T cells, 10 years after primary vaccination. Revaccination restored PRNT seropositivity as well as the levels of effector memory CD4+, CD8+, and interferon-γ+CD8+ T cells. Moreover, secondary or multiple vaccinations guarantee long-term persistence of PRNT positivity and cell-mediated memory 10 years after booster vaccination. These findings support the relevance of booster doses to heighten the 17DD-YF-specific immune response to guarantee the long-term persistence of memory components. Secondary or multiple vaccinations improved the correlates of protection triggered by 17DD-YF primary vaccination, indicating that booster regimens are needed to achieve efficient immunity in areas with high risk for virus transmission.
- Subjects :
- Adolescent
Adult
Aged
Antibodies, Neutralizing immunology
Antibodies, Viral immunology
Brazil epidemiology
Dengue Virus immunology
Female
Humans
Immunity, Cellular
Immunoglobulin G immunology
Immunologic Memory
Male
Middle Aged
Neutralization Tests
Public Health Surveillance
Yellow Fever Vaccine administration & dosage
Young Adult
Immunity
Immunization, Secondary
Yellow Fever immunology
Yellow Fever prevention & control
Yellow Fever Vaccine immunology
Yellow fever virus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1080-6059
- Volume :
- 25
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Emerging infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 31298654
- Full Text :
- https://doi.org/10.3201/eid2508.181432