Intrinsic role of coagulase negative staphylococci norA -like efflux system in fluoroquinolones resistance.

Authors :: Marco L
Liliana G
Anna B
Annarita M
Source :: AIMS microbiology [AIMS Microbiol] 2017 Nov 14; Vol. 3 (4), pp. 908-914. Date of Electronic Publication: 2017 Nov 14 (Print Publication: 2017).
Publication Year :: 2017
Abstract: NorA is a Staphylococcus aureus multidrug transporter that exports structurally distinct compounds including fluoroquinolones. In this study norA- like genes of Staphylococcus epidermidis ( norA <subscript>SEP</subscript> ) and Staphylococcus haemolyticus ( norA <subscript>SHAE</subscript> ) were identified and sequenced. The nucleotide identity of norA <subscript>SEP</subscript> and norA <subscript>SHAE</subscript> with norA was 75.3 and 74.1%, respectively, and the amino acid identity 87.7 and 86%, respectively. Inactivation of norA <subscript>SEP</subscript> increased the ciprofloxacin susceptibility of E. coli DH5α carrying the pB SK 198 norA <subscript>SEP</subscript> EZ cat norA <subscript>SEP</subscript> plasmid.<br />Competing Interests: Conflict of Interest: All authors declare no conflicts of interest in this paper.

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