Cytotoxic phenolic compounds isolated from the fruits of Macaranga denticulata .

Authors :: Le TNV
Truong BN
Le TP
Litaudon M
Tran DT
Chau VM
Mai HDT
Pham VC
Source :: Natural product research [Nat Prod Res] 2021 Jun; Vol. 35 (11), pp. 1861-1868. Date of Electronic Publication: 2019 Jul 11.
Publication Year :: 2021
Abstract: A new modified geranylated flavonoid, 3'-dehydroxy-solophenol C ( 1 ), along with 17 known compounds ( 2 - 18 ) were isolated from the fruits of Macaranga denticulata . Their structures were established by spectral analysis, such as mass spectrometry, 1D-NMR and 2D-NMR. The new geranylated flavonoid 1 showed a moderate cytotoxic activity against the A549 cell line with IC <subscript>50</subscript> value of 16.0 µM. Compound 9 showed the highest cytotoxic activities against KB, HepG2, Lu-1 and MCF7 cell lines with IC <subscript>50</subscript> values of 0.6, 0.8, 1.3 and 1.2 µM, respectively.

Subjects :: Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic pharmacology
Carbon-13 Magnetic Resonance Spectroscopy
Cell Death drug effects
Cell Line, Tumor
Flavonoids chemistry
Flavonoids pharmacology
Humans
Plant Extracts chemistry
Proton Magnetic Resonance Spectroscopy
Spectroscopy, Fourier Transform Infrared
Euphorbiaceae chemistry
Fruit chemistry
Phenols isolation & purification
Phenols pharmacology

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