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Dietary choline is positively related to overall and cause-specific mortality: results from individuals of the National Health and Nutrition Examination Survey and pooling prospective data.
- Source :
-
The British journal of nutrition [Br J Nutr] 2019 Dec 14; Vol. 122 (11), pp. 1262-1270. Date of Electronic Publication: 2019 Nov 06. - Publication Year :
- 2019
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Abstract
- Little is known about the association between dietary choline intake and mortality. We evaluated the link between choline consumption and overall as well as cause-specific mortality by using both individual data and pooling prospective studies by meta-analysis and systematic review. Furthermore, adjusted means of cardiometabolic risk factors across choline intake quartiles were calculated. Data from the National Health and Nutrition Examination Survey (1999-2010) were collected. Adjusted Cox regression was performed to determine the risk ratio (RR) and 95 % CI, as well as random-effects models and generic inverse variance methods to synthesise quantitative and pooling data, followed by a leave-one-out method for sensitivity analysis. After adjustments, we found that individuals consuming more choline had worse lipid profile and glucose homeostasis, but lower C-reactive protein levels (P < 0·001 for all comparisons) with no significant differences in anthropometric parameters and blood pressure. Multivariable Cox regression models revealed that individuals in the highest quartile (Q4) of choline consumption had a greater risk of total (23 %), CVD (33 %) and stroke (30 %) mortality compared with the first quartile (Q1) (P < 0·001 for all comparison). These results were confirmed in a meta-analysis, showing that choline intake was positively and significantly associated with overall (RR 1·12, 95 % CI 1·08, 1·17, I2 = 2·9) and CVD (RR 1·28, 95 % CI 1·17, 1·39, I2 = 9·6) mortality risk. In contrast, the positive association between choline consumption and stroke mortality became non-significant (RR 1·18, 95 % CI 0·97, 1·43, P = 0·092, I2 = 1·1). Our findings shed light on the potential adverse effects of choline intake on selected cardiometabolic risk factors and mortality risk.
- Subjects :
- Adult
Blood Glucose analysis
C-Reactive Protein analysis
Cholesterol analogs & derivatives
Ethnicity
Female
Glycerophospholipids
Humans
Lipids blood
Male
Middle Aged
Odds Ratio
Socioeconomic Factors
Stroke mortality
Cardiovascular Diseases mortality
Choline administration & dosage
Choline adverse effects
Diet
Mortality
Nutrition Surveys
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2662
- Volume :
- 122
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The British journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 31288869
- Full Text :
- https://doi.org/10.1017/S0007114519001065