Back to Search
Start Over
Integration of 68Ga-PSMA-PET/CT in Radiotherapy Planning for Prostate Cancer Patients.
- Source :
-
Clinical nuclear medicine [Clin Nucl Med] 2019 Sep; Vol. 44 (9), pp. e510-e516. - Publication Year :
- 2019
-
Abstract
- To assess the role of Gallium-labeled-prostate-specific membrane antigen PET/CT (Ga-PSMA-PET/CT) in risk group definition and radiotherapy planning in the initially planned definitive radiotherapy (RT) for prostate cancer patients.<br />Methods: The clinical data of 191 prostate cancer patients treated with definitive intensity-modulated RT were retrospectively analyzed. All patients were initially staged with thoracoabdominal CT and bone scintigraphy, and the second staging was performed using Ga-PSMA-PET/CT. Both stages were evaluated for the decision making of RT and any change in RT target volumes.<br />Results: After staging with Ga-PSMA-PET/CT, 26 patients (13.6%) had risk group changes, 16 patients (8.4%) had an increase in risk group, and 10 patients (5.2%) had a decrease in risk group. Down-staging occurred in 22 patients (11.5%), and upstaging was observed in 30 patients (15.7%). A total of 26 patients (13.6%) had nodal stage changes. After the Ga-PSMA-PET/CT scans, the number of metastatic patient increased to 17 (8.9%), with 4 of them moving from oligo- to polymetastatic disease. An additional irradiation of pelvic lymphatics and metastatic site was performed in 13 patients (6.8%) and 6 patients (3.2%), respectively. The RT was aborted in 4 patients (2.1%) because of parenchymal or distant site metastasis observed in the Ga-PSMA-PET/CT.<br />Conclusions: We found that Ga-PSMA-PET/CT causes considerable migration in stage, risk group, and RT field arrangements, especially in high-risk patients regardless of the GS and baseline prostate-specific antigen values alone. Ga-PSMA-PET/CT seems to have a great influence on RT decision making in prostate cancer patients.
- Subjects :
- Aged
Aged, 80 and over
Gallium Isotopes
Gallium Radioisotopes
Humans
Male
Middle Aged
Neoplasm Metastasis
Prostatic Neoplasms pathology
Radiotherapy, Intensity-Modulated
Retrospective Studies
Edetic Acid analogs & derivatives
Oligopeptides
Positron Emission Tomography Computed Tomography
Prostatic Neoplasms diagnostic imaging
Prostatic Neoplasms radiotherapy
Radiotherapy Planning, Computer-Assisted methods
Subjects
Details
- Language :
- English
- ISSN :
- 1536-0229
- Volume :
- 44
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Clinical nuclear medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31283600
- Full Text :
- https://doi.org/10.1097/RLU.0000000000002691