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Conditioned aversive memory associated with morphine withdrawal increases brain-derived neurotrophic factor in dentate gyrus and basolateral amygdala.
- Source :
-
Addiction biology [Addict Biol] 2020 Jul; Vol. 25 (4), pp. e12792. Date of Electronic Publication: 2019 Jul 08. - Publication Year :
- 2020
-
Abstract
- Morphine has been shown to increase the expression of brain-derived neurotrophic factor (BDNF) in the brain. However, little is known about the effect of conditioned naloxone-precipitated morphine withdrawal on BDNF and its precursor protein, proBDNF. We used the conditioned place aversion (CPA) paradigm to evaluate the role of corticotropin-releasing factor (CRF)/CRF1 receptor signaling on the BDNF expression and corticosterone plasma levels after CPA expression and extinction. Male mice were rendered dependent on morphine and injected acutely with naloxone before paired to confinement in a naloxone-associated compartment. The expression of BDNF and proBDNF in the dentate gyrus (DG) and basolateral amygdala (BLA) was measured in parallel with the corticosterone plasma levels with and without CRF1 receptor blockade. Mice subjected to conditioned naloxone-induced morphine withdrawal showed an increased expression of BDNF (in DG and BLA) in parallel with an enhancement of corticosterone plasma levels. These results demonstrated that BDNF expression together with the increased activity of hypothalamic-pituitary-adrenocortical (HPA) axis are critical to the acquisition of aversive memory. However, we have observed a decrease in corticosterone plasma levels and BDNF expression after CPA extinction reaffirming the importance of BDNF in the maintenance of aversive memory. In addition, the pre-treatment with the CRF1 receptor antagonist CP-154 526 before naloxone conditioning session impaired morphine withdrawal-induced aversive memory acquisition, the increased corticosterone plasma levels, and the expression of BDNF observed after CPA expression in the DG and BLA. Altogether, present results are suggesting a clear connection between HPA axis and BDNF in the formation and extinction of aversive memory.<br /> (© 2019 Society for the Study of Addiction.)
- Subjects :
- Affect
Analgesics, Opioid adverse effects
Animals
Conditioning, Classical
Corticosterone metabolism
Cyclic AMP Response Element-Binding Protein metabolism
Extinction, Psychological
Male
Mice
Mitogen-Activated Protein Kinase 1 metabolism
Mitogen-Activated Protein Kinase 3 metabolism
Morphine adverse effects
Naloxone pharmacology
Narcotic Antagonists pharmacology
Protein Precursors metabolism
Pyrimidines pharmacology
Pyrroles pharmacology
Receptors, Corticotropin-Releasing Hormone antagonists & inhibitors
Substance Withdrawal Syndrome etiology
Basolateral Nuclear Complex metabolism
Brain-Derived Neurotrophic Factor metabolism
Corticotropin-Releasing Hormone metabolism
Dentate Gyrus metabolism
Memory
Receptors, Corticotropin-Releasing Hormone metabolism
Substance Withdrawal Syndrome metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1369-1600
- Volume :
- 25
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Addiction biology
- Publication Type :
- Academic Journal
- Accession number :
- 31282111
- Full Text :
- https://doi.org/10.1111/adb.12792