Rapid response to 2'-deoxycoformycin in advanced hairy cell leukemia after failure of interferons alpha and gamma.

Authors :: Lembersky BC
Ratain MJ
Westbrook C
Golomb HM
Source :: American journal of hematology [Am J Hematol] 1988 Jan; Vol. 27 (1), pp. 60-2.
Publication Year :: 1988
Abstract: A patient with advanced hairy cell leukemia initially had a short-lived minor response to interferon alpha therapy and failed to respond to interferon gamma. Subsequent treatment with 2'-deoxycoformycin (dCF) administered biweekly for 12 wk resulted in a complete hematological remission which has continued for 16 months without additional therapy.

Subjects :: Coformycin analogs & derivatives
Drug Resistance
Humans
Leukemia, Hairy Cell pathology
Male
Middle Aged
Pentostatin
Remission Induction
Antineoplastic Agents therapeutic use
Coformycin therapeutic use
Interferon Type I therapeutic use
Interferon-gamma therapeutic use
Leukemia, Hairy Cell drug therapy
Ribonucleosides therapeutic use

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