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Why toxicologists resisted and radiation geneticists supported EPA'S adoption of LNT for cancer risk assessment.

Authors :
Calabrese EJ
Golden RJ
Source :
Chemico-biological interactions [Chem Biol Interact] 2019 Sep 01; Vol. 310, pp. 108736. Date of Electronic Publication: 2019 Jul 03.
Publication Year :
2019

Abstract

The linear non-threshold (LNT) dose response model for cancer risk assessment has been a controversial concept since its initial proposal during the 1930s. It was long advocated by the radiation genetics community in the 1950s, some two decades prior to being generally adopted within the chemical toxicology community. This paper explores possible reasons for such major differences in the acceptance of LNT for cancer risk assessment by these two key groups of scientists.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1872-7786
Volume :
310
Database :
MEDLINE
Journal :
Chemico-biological interactions
Publication Type :
Academic Journal
Accession number :
31278902
Full Text :
https://doi.org/10.1016/j.cbi.2019.108736