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Role of complement in patients with autoimmune hemolytic anemia and platelet transfusion refractoriness.
- Source :
-
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine [Transfus Clin Biol] 2019 Sep; Vol. 26 (3), pp. 152-154. Date of Electronic Publication: 2019 Jun 19. - Publication Year :
- 2019
-
Abstract
- The complement is a key player of the innate immune response. It provides defense mechanisms that are not specific, but very efficient at neutralizing any invader, accounting for 4% of the proteins in the peripheral blood. Nevertheless, there is a dark side to the complement system, as it may activate its machinery against healthy cells such as peripheral blood red blood cells and platelets resulting in undesired hemolysis and thrombocytopenia, respectively. Understanding and identifying the role of complement in these settings allow physicians to adjust their diagnostic and therapeutic modalities accordingly. The role of complement in the pathophysiology and management of autoimmune hemolytic anemia and of alloimmune-mediated thrombocytopenia is under investigation and discussed.<br /> (Copyright © 2019 Société française de transfusion sanguine (SFTS). Published by Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Anemia, Hemolytic, Autoimmune therapy
Antibody Specificity
Antigens, Human Platelet immunology
Antilymphocyte Serum blood
Antilymphocyte Serum immunology
Autoantibodies blood
Autoantibodies immunology
Humans
Immunoglobulin G immunology
Immunoglobulin M immunology
Anemia, Hemolytic, Autoimmune immunology
Complement System Proteins immunology
Immunity, Innate immunology
Platelet Transfusion
Subjects
Details
- Language :
- English
- ISSN :
- 1953-8022
- Volume :
- 26
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
- Publication Type :
- Academic Journal
- Accession number :
- 31277985
- Full Text :
- https://doi.org/10.1016/j.tracli.2019.06.232