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Ameliorating the Fibrotic Remodeling of the Heart through Direct Cardiac Reprogramming.
- Source :
-
Cells [Cells] 2019 Jul 04; Vol. 8 (7). Date of Electronic Publication: 2019 Jul 04. - Publication Year :
- 2019
-
Abstract
- Coronary artery disease is the most common form of cardiovascular diseases, resulting in the loss of cardiomyocytes (CM) at the site of ischemic injury. To compensate for the loss of CMs, cardiac fibroblasts quickly respond to injury and initiate cardiac remodeling in an injured heart. In the remodeling process, cardiac fibroblasts proliferate and differentiate into myofibroblasts, which secrete extracellular matrix to support the intact structure of the heart, and eventually differentiate into matrifibrocytes to form chronic scar tissue. Discovery of direct cardiac reprogramming offers a promising therapeutic strategy to prevent/attenuate this pathologic remodeling and replace the cardiac fibrotic scar with myocardium in situ . Since the first discovery in 2010, many progresses have been made to improve the efficiency and efficacy of reprogramming by understanding the mechanisms and signaling pathways that are activated during direct cardiac reprogramming. Here, we overview the development and recent progresses of direct cardiac reprogramming and discuss future directions in order to translate this promising technology into an effective therapeutic paradigm to reverse cardiac pathological remodeling in an injured heart.<br />Competing Interests: The authors declare no conflicts of interest.
- Subjects :
- Animals
Coronary Artery Disease pathology
Disease Models, Animal
Extracellular Matrix pathology
Fibrosis
Gene Expression Regulation
Genetic Vectors administration & dosage
Genetic Vectors genetics
Humans
Injections, Intralesional
Myocardium cytology
Myocytes, Cardiac physiology
Myofibroblasts physiology
Signal Transduction genetics
Transcription Factors metabolism
Cellular Reprogramming genetics
Coronary Artery Disease therapy
Myocardium pathology
Regenerative Medicine methods
Transcription Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2073-4409
- Volume :
- 8
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Cells
- Publication Type :
- Academic Journal
- Accession number :
- 31277520
- Full Text :
- https://doi.org/10.3390/cells8070679