Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria.

Authors :: Vasconcelos NG
Croda J
Silva KE
Motta MLL
Maciel WG
Limiere LC
Simionatto S
Source :: Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2019 Jun 27; Vol. 52, pp. e20180502. Date of Electronic Publication: 2019 Jun 27.
Publication Year :: 2019
Abstract: Introduction: Plant products are sources for drug development against multidrug resistant bacteria.<br />Methods: The antimicrobial activity of Origanum vulgare L. essential oil (OVeo) against carbapenem-resistant strains was assessed by disk-diffusion, microdilution (REMA-Resazurin Microtiter Assay), and time kill assays.<br />Results: Carbapenemase production was confirmed for all strains. OVeo exhibited a minimum inhibitory concentration of 0.059% v/v for Klebsiella pneumoniae and Serratia marcescens, and of 0.015 % v/v for Acinetobacter baumannii. A decrease in cell count was observed after a 4 h treatment.<br />Conclusions: OVeo antimicrobial effect was rapid and consistent, making it a candidate for developing alternative therapeutic options against carbapenem-resistant strains.

Subjects :: Acinetobacter baumannii growth & development
Anti-Bacterial Agents classification
Bacterial Proteins
Carbapenems pharmacology
Drug Resistance, Multiple, Bacterial
Gram-Negative Bacteria growth & development
Humans
Klebsiella pneumoniae growth & development
Microbial Sensitivity Tests
Serratia marcescens growth & development
beta-Lactamases
Acinetobacter baumannii drug effects
Anti-Bacterial Agents pharmacology
Gram-Negative Bacteria drug effects
Klebsiella pneumoniae drug effects
Oils, Volatile pharmacology
Origanum chemistry
Serratia marcescens drug effects

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