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Mammary stem cells and progenitors: targeting the roots of breast cancer for prevention.
- Source :
-
The EMBO journal [EMBO J] 2019 Jul 15; Vol. 38 (14), pp. e100852. Date of Electronic Publication: 2019 Jun 21. - Publication Year :
- 2019
-
Abstract
- Breast cancer prevention is daunting, yet not an unsurmountable goal. Mammary stem and progenitors have been proposed as the cells-of-origin in breast cancer. Here, we present the concept of limiting these breast cancer precursors as a risk reduction approach in high-risk women. A wealth of information now exists for phenotypic and functional characterization of mammary stem and progenitor cells in mouse and human. Recent work has also revealed the hormonal regulation of stem/progenitor dynamics as well as intrinsic lineage distinctions between mammary epithelial populations. Leveraging these insights, molecular marker-guided chemoprevention is an achievable reality.<br /> (© 2019 The Authors. Published under the terms of the CC BY 4.0 license.)
- Subjects :
- Animals
Biomarkers, Tumor metabolism
Breast Neoplasms metabolism
Female
Humans
Mammary Glands, Animal cytology
Mammary Glands, Animal metabolism
Mammary Glands, Animal pathology
Mammary Glands, Human metabolism
Mammary Glands, Human pathology
Mice
Signal Transduction
Stem Cells metabolism
Stem Cells pathology
Breast Neoplasms pathology
Mammary Glands, Human cytology
Stem Cells cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2075
- Volume :
- 38
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- The EMBO journal
- Publication Type :
- Academic Journal
- Accession number :
- 31267556
- Full Text :
- https://doi.org/10.15252/embj.2018100852