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Meiotic viral attenuation through an ancestral apoptotic pathway.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Aug 13; Vol. 116 (33), pp. 16454-16462. Date of Electronic Publication: 2019 Jul 02. - Publication Year :
- 2019
-
Abstract
- The programmed release of apoptogenic proteins from mitochondria is a core event of apoptosis, although ancestral roles of this phenomenon are not known. In mammals, one such apoptogenic protein is Endonuclease G (EndoG), a conserved mitochondrial nuclease that fragments the DNA of dying cells. In this work, we show that budding yeast executes meiotically programmed mitochondrial release of an EndoG homolog, Nuc1, during sporulation. In contrast to EndoG's ostensible pro-death function during apoptosis, Nuc1 mitochondrial release is pro-survival, attenuating the cytosolic L-A and Killer double-stranded RNA mycoviruses and protecting meiotic progeny from the catastrophic consequences of their derepression. The protective viral attenuation role of this pathway illuminates a primordial role for mitochondrial release of EndoG, and perhaps of apoptosis itself.<br />Competing Interests: The authors declare no conflict of interest.<br /> (Copyright © 2019 the Author(s). Published by PNAS.)
- Subjects :
- Animals
Endodeoxyribonucleases genetics
Mammals
Mitochondria enzymology
Mitochondria genetics
Saccharomycetales growth & development
Saccharomycetales virology
Spores, Fungal genetics
Spores, Fungal growth & development
Apoptosis genetics
Endonucleases genetics
Exonucleases genetics
Meiosis genetics
Saccharomyces cerevisiae Proteins genetics
Saccharomycetales genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 116
- Issue :
- 33
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 31266891
- Full Text :
- https://doi.org/10.1073/pnas.1900751116