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Antiretroviral Effects on HBV/HIV Co-infection and the Natural History of Liver Disease.
- Source :
-
Clinics in liver disease [Clin Liver Dis] 2019 Aug; Vol. 23 (3), pp. 473-486. Date of Electronic Publication: 2019 May 24. - Publication Year :
- 2019
-
Abstract
- Hepatitis B virus (HBV) coinfection is common in persons with human immunodeficiency virus (HIV) infection, contributing significantly to morbidity and mortality. Many currently used HIV antiretroviral therapy (ART) regimens provide potent anti-HBV activity and it is recommended that HBV-HIV coinfected persons be treated with ART regimens containing tenofovir. ART has multiple benefits, including increasing rates of HBV clearance after initial infection and potent suppression of HBV DNA in chronic infection. Nevertheless, long-term studies have yet to demonstrate a profound positive impact of ART on HBV-related fibrosis progression and development of endstage liver disease.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Coinfection diagnosis
Coinfection epidemiology
DNA, Viral drug effects
Disease Progression
Female
HIV drug effects
HIV isolation & purification
HIV Infections diagnosis
Hepatitis B virus drug effects
Hepatitis B virus isolation & purification
Hepatitis B, Chronic diagnosis
Hepatitis B, Chronic epidemiology
Humans
Liver Cirrhosis pathology
Liver Cirrhosis virology
Male
Prevalence
Prognosis
Risk Assessment
Survival Analysis
Tenofovir therapeutic use
Treatment Outcome
Anti-Retroviral Agents therapeutic use
Coinfection drug therapy
HIV Infections drug therapy
HIV Infections epidemiology
Hepatitis B, Chronic drug therapy
Liver Cirrhosis epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8224
- Volume :
- 23
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinics in liver disease
- Publication Type :
- Academic Journal
- Accession number :
- 31266621
- Full Text :
- https://doi.org/10.1016/j.cld.2019.04.004