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Pituitary Adenomas: What Are the Key Features? What Are the Current Treatments? Where Is the Future Taking Us?
- Source :
-
World neurosurgery [World Neurosurg] 2019 Jul; Vol. 127, pp. 695-709. - Publication Year :
- 2019
-
Abstract
- Pituitary tumors are a heterogeneous group of lesions (usually benign) and proper understanding of the anatomy, physiology, and pathology of the hypothalamic/pituitary region is essential to make an accurate diagnosis and define the essential treatment options (i.e., surgery, medical therapies, and radiotherapy, alone or in combination). Surgery is the primary treatment for acromegaly, Cushing disease, thyroid-stimulating hormone-secreting adenomas, resistant prolactinomas, and nonfunctioning pituitary adenomas causing mass effect. Medical and radiation therapy are reserved in cases in which surgery is not possible or does not provide a complete cure. In the last decades, tremendous innovations (i.e., targeted drugs and refined surgical tools and techniques) have expanded the treatment strategies for pituitary adenomas. We herein report the current indications for and depiction of the surgical techniques in pituitary surgery, review current medical treatments, and provide a glimpse of future possibilities.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- ACTH-Secreting Pituitary Adenoma pathology
ACTH-Secreting Pituitary Adenoma therapy
Adenoma pathology
Adrenergic Antagonists therapeutic use
Dopamine Agonists therapeutic use
Drug Therapy, Combination
Forecasting
Growth Hormone-Secreting Pituitary Adenoma pathology
Growth Hormone-Secreting Pituitary Adenoma therapy
Humans
Nasal Surgical Procedures methods
Neuroendoscopy methods
Neuroendoscopy trends
Pituitary Gland surgery
Pituitary Neoplasms pathology
Postoperative Care
Prolactinoma pathology
Prolactinoma therapy
Radiosurgery methods
Receptors, Glucocorticoid antagonists & inhibitors
Steroid Synthesis Inhibitors therapeutic use
Adenoma therapy
Pituitary Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1878-8769
- Volume :
- 127
- Database :
- MEDLINE
- Journal :
- World neurosurgery
- Publication Type :
- Academic Journal
- Accession number :
- 31266132
- Full Text :
- https://doi.org/10.1016/j.wneu.2019.03.049