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Clinical and dosimetric predictors of physician and patient reported xerostomia following intensity modulated radiotherapy for nasopharyngeal cancer - A prospective cohort analysis.
- Source :
-
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2019 Sep; Vol. 138, pp. 149-157. Date of Electronic Publication: 2019 Jun 29. - Publication Year :
- 2019
-
Abstract
- Background and Purpose: To compare physician and patient reported xerostomia and correlate xerostomia with dosimetric and clinical parameters for nasopharyngeal cancer (NPC) patients treated with intensity modulated radiotherapy (IMRT) and chemotherapy.<br />Patients and Methods: We analyzed the data of 172 patients with locally advanced NPC. Xerostomia was evaluated via physician-rated xerostomia based on RTOG morbidity score (E1), patient-rated dry mouth (E2) and patient-rated sticky saliva (E3) based on EORTC QLQ-HN35 questionnaire. Primary endpoint was the presence of moderate to severe xerostomia at 2-year after completion of IMRT.<br />Results: The levels of physician reported xerostomia (E1) were consistently lower than patient reported dry mouth (E2) over time. The incidence of patients with xerostomia at 3-month post RT was 58% based on E1, 70% based on E2, and 51% based on E3. The corresponding incidence rates at 2-year post RT was 26% (E1), 36% (E2) and 21% (E3). The incidence of patients with xerostomia at 1-year post RT was close to that at 2-year post RT for all the 3 endpoints. The average Dmean of parotid glands was 41.5 Gy (range: 31.0 Gy-65.9 Gy, median: 40.7 Gy). No dosimetric parameters were significantly associated with xerostomia.<br />Conclusion: Significant proportion of patients still experienced long term xerostomia with IMRT. Dose-effect relationships between xerostomia and the parotid glands were not observed in this study.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Aged
Clinical Trials, Phase II as Topic
Clinical Trials, Phase III as Topic
Cohort Studies
Dose-Response Relationship, Radiation
Female
Humans
Male
Middle Aged
Parotid Gland radiation effects
Patient Reported Outcome Measures
Prospective Studies
Radiation Injuries diagnosis
Radiotherapy, Intensity-Modulated adverse effects
Randomized Controlled Trials as Topic
Surveys and Questionnaires
Xerostomia diagnosis
Young Adult
Nasopharyngeal Carcinoma radiotherapy
Nasopharyngeal Neoplasms radiotherapy
Radiation Injuries etiology
Xerostomia etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0887
- Volume :
- 138
- Database :
- MEDLINE
- Journal :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 31265972
- Full Text :
- https://doi.org/10.1016/j.radonc.2019.05.023