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Anxiolytic Effect of Cedrol on Behavior and Brain Neurotransmitter Levels of Female Mice.
- Source :
-
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2019 Sep 01; Vol. 42 (9), pp. 1575-1580. Date of Electronic Publication: 2019 Jun 29. - Publication Year :
- 2019
-
Abstract
- Cedrol has been reported to be effective in reducing anxiety of male mice. The limited application of females in animal models of anxiety makes it difficult to systematically investigate new drug substitutes with potential anxiolytic activity. In the present study, we investigated the behavioral response of female ICR mice to cedrol after intraperitoneal (i.p.) administration using the elevated plus maze (EPM) and the light-dark box (LDB) test, followed by determination of neurochemical changes in brain. The data suggested that cedrol at dose of 1200-1600 mg·kg <superscript>-1</superscript> exhibited anxiolytic activity on the female mice, as reflected by greater percentage of entries into the open arms and time spent in the open arms in the EPM, and greater transitions between chambers and percentage of time spent in the light chamber in the LDB. Cedrol increased the level of 5-hydroxytryptamine (5-HT), decreased the level of dopamine (DA), reduced the ratio of 5-hydroxyindoleacetic acid (5-HIAA)/5-HT and increased the ratio of 3,4-dihydroxyphenyl acetic acid (DOPAC)/DA, compared with the control group, indicative of an anxiolytic-like effect on female mice via the 5-HTnergic or DAnergic pathways.
- Subjects :
- 3,4-Dihydroxyphenylacetic Acid metabolism
Animals
Anxiety metabolism
Behavior, Animal drug effects
Biogenic Monoamines metabolism
Brain metabolism
Female
Homovanillic Acid metabolism
Hydroxyindoleacetic Acid metabolism
Maze Learning drug effects
Mice, Inbred ICR
Motor Activity drug effects
Anti-Anxiety Agents pharmacology
Anti-Anxiety Agents therapeutic use
Anxiety drug therapy
Brain drug effects
Neurotransmitter Agents metabolism
Polycyclic Sesquiterpenes pharmacology
Polycyclic Sesquiterpenes therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1347-5215
- Volume :
- 42
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Biological & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 31257273
- Full Text :
- https://doi.org/10.1248/bpb.b19-00380