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What is (not) known about the dynamics of the human gut virome in health and disease.
- Source :
-
Current opinion in virology [Curr Opin Virol] 2019 Aug; Vol. 37, pp. 52-57. Date of Electronic Publication: 2019 Jun 27. - Publication Year :
- 2019
-
Abstract
- The human gut virome has an important role in human health but its dynamics remain poorly understood. Few longitudinal studies in healthy adults showed a stable temporal gut virome, with high inter-individual diversity. In contrast, the infant virome shows a high temporal intra-individual diversity. Unfortunately, these virome studies ignore an enormous amount of unknown 'dark matter' sequences, leading to incomplete analyses and possibly incorrect conclusions. Also, the interactions between prokaryotes and bacteriophages in the gut seem to be too complex for currently available models. Therefore, there is a huge need of larger longitudinal cohort studies focusing on both the bacterial and viral component of the microbiome to be able to describe and understand this complex ecosystem.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Anti-Bacterial Agents adverse effects
Autoimmune Diseases virology
Bacteria virology
DNA, Viral
Diet
Female
Gastrointestinal Tract microbiology
Gastrointestinal Tract pathology
Humans
Infant
Inflammatory Bowel Diseases virology
Intestinal Diseases
Male
Microbial Interactions
Natural Childbirth
Symbiosis
Viruses pathogenicity
Bacteriophages immunology
Gastrointestinal Microbiome
Gastrointestinal Tract virology
Host Microbial Interactions
Subjects
Details
- Language :
- English
- ISSN :
- 1879-6265
- Volume :
- 37
- Database :
- MEDLINE
- Journal :
- Current opinion in virology
- Publication Type :
- Academic Journal
- Accession number :
- 31255903
- Full Text :
- https://doi.org/10.1016/j.coviro.2019.05.013