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Flavonoid glycosides from seeds of Hippophae rhamnoides subsp. Sinensis with α-glucosidase inhibition activity.
- Source :
-
Fitoterapia [Fitoterapia] 2019 Sep; Vol. 137, pp. 104248. Date of Electronic Publication: 2019 Jun 25. - Publication Year :
- 2019
-
Abstract
- Hippophae rhamnoides subsp. Sinensis is a famous traditional medicinal plant in Tibet and Mongolia of China. Three novel flavonoid glycosides and ten known analogues were obtained from the seeds of H. rhamnoides. The structures of new compounds were elucidated by spectroscopics, chemical methods as well as literature data. In vitro assay, compounds 5-9, kaempferol and 70% ethanolic elution fraction showed prominent α-glucosidase inhibitory activities with IC <subscript>50</subscript> values ranging from 8.30 to 112.11 μM, better than that of the positive control, acarbose, whose IC <subscript>50</subscript> value was 1727.07 μM.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- China
Flavonoids isolation & purification
Glycoside Hydrolase Inhibitors isolation & purification
Glycosides isolation & purification
Molecular Structure
Phytochemicals isolation & purification
Phytochemicals pharmacology
Plants, Medicinal chemistry
Seeds chemistry
alpha-Glucosidases
Flavonoids pharmacology
Glycoside Hydrolase Inhibitors pharmacology
Glycosides pharmacology
Hippophae chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 137
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 31247218
- Full Text :
- https://doi.org/10.1016/j.fitote.2019.104248