State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment.

Authors :: Mukhina AY
Medvedeva OA
Svishcheva MV
Shevchenko AV
Efremova NN
Bobyntsev II
Kalutskii PV
Andreeva LA
Myasoedov NF
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2019 Jun; Vol. 167 (2), pp. 226-228. Date of Electronic Publication: 2019 Jun 24.
Publication Year :: 2019
Abstract: We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure. Chronic restraint stress led to a decrease in the content of obligate microflora, while the content of opportunistic microorganisms increased. Selank restored intestinal microbiota presumably via central (neurotropic) and peripheral (immunotropic) mechanisms.

Subjects :: Animals
Disease Models, Animal
Male
Rats
Rats, Wistar
Colon microbiology
Gastrointestinal Microbiome drug effects
Oligopeptides therapeutic use
Restraint, Physical physiology

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