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Chronic inflammatory diseases, anti-inflammatory medications and risk of prostate cancer: a population-based case-control study.
- Source :
-
BMC cancer [BMC Cancer] 2019 Jun 21; Vol. 19 (1), pp. 612. Date of Electronic Publication: 2019 Jun 21. - Publication Year :
- 2019
-
Abstract
- Background: Whether chronic inflammation increases prostate cancer risk remains unclear. This study investigated whether chronic inflammatory diseases (CID) or anti-inflammatory medication use (AIM) were associated with prostate cancer risk.<br />Methods: Fifty-five thousand nine hundred thirty-seven cases (all prostate cancer, 2007-2012) and 279,618 age-matched controls were selected from the Prostate Cancer Database Sweden. CIDs and AIMs was determined from national patient and drug registers. Associations were investigated using conditional logistic regression, including for disease/drug subtypes and exposure length/dose.<br />Results: Men with a history of any CID had slightly increased risk of any prostate cancer diagnosis (OR: 1.08; 95%CI: 1.04-1.12) but not 'unfavourable' (high-risk or advanced) prostate cancer. Generally, risk of prostate cancer was highest for shorter exposure times. However, a positive association was observed for asthma > 5 years before prostate cancer diagnosis (OR: 1.21; 95%CI: 1.05-1.40). Risk of prostate cancer was increased with prior use of any AIMs (OR: 1.26; 95%CI: 1.24-1.29). A positive trend with increasing cumulative dose was only observed for inhaled glucocorticoids (p < 0.011).<br />Conclusion: Detection bias most likely explains the elevated risk of prostate cancer with prior history of CIDs or use of AIMs, given the higher risk immediately after first CID event and lack of dose response. However, findings for length of time with asthma and dose of inhaled glucocorticoids suggest that asthma may increase risk of prostate cancer through other pathways.
- Subjects :
- Administration, Inhalation
Aged
Aged, 80 and over
Asthma drug therapy
Case-Control Studies
Dose-Response Relationship, Drug
Glucocorticoids administration & dosage
Glucocorticoids adverse effects
Humans
Hypersensitivity complications
Hypersensitivity drug therapy
Immunosuppressive Agents adverse effects
Incidence
Logistic Models
Male
Middle Aged
Risk
Sweden
Asthma complications
Glucocorticoids therapeutic use
Immunosuppressive Agents therapeutic use
Inflammation complications
Inflammation drug therapy
Prostatic Neoplasms epidemiology
Prostatic Neoplasms etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 31226970
- Full Text :
- https://doi.org/10.1186/s12885-019-5846-3