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Differences in Trabecular Plate and Rod Structure in Premenopausal Women Across the Weight Spectrum.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2019 Oct 01; Vol. 104 (10), pp. 4501-4510. - Publication Year :
- 2019
-
Abstract
- Context: Premenopausal women with anorexia nervosa (AN) and obesity (OB) have elevated fracture risk. More plate-like and axially aligned trabecular bone, assessed by individual trabeculae segmentation (ITS), is associated with higher estimated bone strength. Trabecular plate and rod structure has not been reported across the weight spectrum.<br />Objective: To investigate trabecular plate and rod structure in premenopausal women.<br />Design: Cross-sectional study.<br />Setting: Clinical research center.<br />Participants: A total of 105 women age 21 to 46 years: (i) women with AN (n = 46), (ii) eumenorrheic lean healthy controls (HCs) (n = 29), and (iii) eumenorrheic women with OB (n = 30).<br />Measures: Trabecular microarchitecture by ITS.<br />Results: Mean age (±SD) was similar (28.9 ± 6.3 years) and body mass index differed (16.7 ± 1.8 vs 22.6 ± 1.4 vs 35.1 ± 3.3 kg/m2; P < 0.0001) across groups. Bone was less plate-like and axially aligned in AN (P ≤ 0.01) and did not differ between OB and HC. After controlling for weight, plate and axial bone volume fraction and plate number density were lower in OB vs HC; some were lower in OB than AN (P < 0.05). The relationship between weight and plate variables was quadratic (R = 0.39 to 0.70; P ≤ 0.0006) (i.e., positive associations were attenuated at high weight). Appendicular lean mass and IGF-1 levels were positively associated with plate variables (R = 0.27 to 0.67; P < 0.05). Amenorrhea was associated with lower radial plate variables than eumenorrhea in AN (P < 0.05).<br />Conclusions: In women with AN, trabecular bone is less plate-like. In women with OB, trabecular plates do not adapt to high weight. This is relevant because trabecular plates are associated with greater estimated bone strength. Higher muscle mass and IGF-1 levels may mitigate some of the adverse effects of low weight or excess adiposity on bone.<br /> (Copyright © 2019 Endocrine Society.)
- Subjects :
- Absorptiometry, Photon
Adult
Amenorrhea etiology
Anorexia Nervosa complications
Anorexia Nervosa metabolism
Body Composition
Body Mass Index
Cancellous Bone physiopathology
Case-Control Studies
Computer Simulation
Female
Femur Neck diagnostic imaging
Finite Element Analysis
Fractures, Bone
Healthy Volunteers
Humans
Insulin-Like Growth Factor I metabolism
Middle Aged
Muscle, Skeletal
Obesity metabolism
Radius physiopathology
Spine diagnostic imaging
Tibia physiopathology
Tomography, X-Ray Computed
Vitamin D analogs & derivatives
Vitamin D metabolism
Weight-Bearing physiology
Young Adult
Anorexia Nervosa diagnostic imaging
Cancellous Bone diagnostic imaging
Obesity diagnostic imaging
Premenopause
Radius diagnostic imaging
Tibia diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7197
- Volume :
- 104
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 31219580
- Full Text :
- https://doi.org/10.1210/jc.2019-00843