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Prevalence and characterization of β-lactamase-producing Enterobacteriaceae in healthy human carriers.
- Source :
-
International microbiology : the official journal of the Spanish Society for Microbiology [Int Microbiol] 2020 May; Vol. 23 (2), pp. 171-177. Date of Electronic Publication: 2019 Jun 19. - Publication Year :
- 2020
-
Abstract
- Presence of extended-spectrum β-lactamase (ESBL-E), AmpC-producing and carbapenemase-producing (CPE) Enterobacteriaceae has been observed not only in the clinical environment, but also in the out-of-hospital environment. The objective of this study was to isolate and characterize strains of ESBL, AmpC, and CPE present in feces of healthy carriers in Navarra (n = 125). Despite the fact that no CPE strains were isolated, 16% and 11.2% of the studied population were ESBL-E and AmpC carriers, respectively. No significant differences were found by gender or age; young people (5-18 years old) showed the highest ESBL-E prevalence (31.8%). The isolates corresponded to E. coli (57.1%), Enterobacter spp. (28.6%), and Citrobacter freundii (14.3%), and all strains showed multidrug-resistant profiles. High resistance against cephalosporins, penicillins, and monobactams, and sensitivity to carbapenems, quinolones, and aminoglycosides were observed. With respect to ESBL producers, 52.4% were CTX-M-type (19.0% CTX-M-14, 9.5% CTX-M-1, and 28.6% CTX-M-15) and 47.6% were TEM-type (38.1% TEM-171). These results confirm the extensive dissemination of these resistances among a healthy population and pose the need to implement control measures and strategies according to the One Health approach in order to prevent the increase of severe and untreatable infections in a not far future.
- Subjects :
- Adolescent
Adult
Aged
Anti-Bacterial Agents pharmacology
Bacterial Proteins genetics
Cephalosporins pharmacology
Child
Child, Preschool
Citrobacter freundii drug effects
Citrobacter freundii isolation & purification
Citrobacter freundii metabolism
Enterobacter drug effects
Enterobacter isolation & purification
Enterobacter metabolism
Escherichia coli drug effects
Escherichia coli isolation & purification
Escherichia coli metabolism
Female
Healthy Volunteers
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Monobactams pharmacology
Multilocus Sequence Typing
Penicillins pharmacology
Prevalence
Young Adult
Drug Resistance, Multiple, Bacterial genetics
Enterobacteriaceae drug effects
Enterobacteriaceae isolation & purification
Enterobacteriaceae metabolism
Feces microbiology
beta-Lactamases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1618-1905
- Volume :
- 23
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International microbiology : the official journal of the Spanish Society for Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 31218538
- Full Text :
- https://doi.org/10.1007/s10123-019-00087-z