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Prevalence and characterization of β-lactamase-producing Enterobacteriaceae in healthy human carriers.

Authors :
González D
Gallagher E
Zúñiga T
Leiva J
Vitas AI
Source :
International microbiology : the official journal of the Spanish Society for Microbiology [Int Microbiol] 2020 May; Vol. 23 (2), pp. 171-177. Date of Electronic Publication: 2019 Jun 19.
Publication Year :
2020

Abstract

Presence of extended-spectrum β-lactamase (ESBL-E), AmpC-producing and carbapenemase-producing (CPE) Enterobacteriaceae has been observed not only in the clinical environment, but also in the out-of-hospital environment. The objective of this study was to isolate and characterize strains of ESBL, AmpC, and CPE present in feces of healthy carriers in Navarra (n = 125). Despite the fact that no CPE strains were isolated, 16% and 11.2% of the studied population were ESBL-E and AmpC carriers, respectively. No significant differences were found by gender or age; young people (5-18 years old) showed the highest ESBL-E prevalence (31.8%). The isolates corresponded to E. coli (57.1%), Enterobacter spp. (28.6%), and Citrobacter freundii (14.3%), and all strains showed multidrug-resistant profiles. High resistance against cephalosporins, penicillins, and monobactams, and sensitivity to carbapenems, quinolones, and aminoglycosides were observed. With respect to ESBL producers, 52.4% were CTX-M-type (19.0% CTX-M-14, 9.5% CTX-M-1, and 28.6% CTX-M-15) and 47.6% were TEM-type (38.1% TEM-171). These results confirm the extensive dissemination of these resistances among a healthy population and pose the need to implement control measures and strategies according to the One Health approach in order to prevent the increase of severe and untreatable infections in a not far future.

Details

Language :
English
ISSN :
1618-1905
Volume :
23
Issue :
2
Database :
MEDLINE
Journal :
International microbiology : the official journal of the Spanish Society for Microbiology
Publication Type :
Academic Journal
Accession number :
31218538
Full Text :
https://doi.org/10.1007/s10123-019-00087-z