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Amelioration of obsessive-compulsive disorder in three mouse models treated with one epigenetic drug: unraveling the underlying mechanism.
- Source :
-
Scientific reports [Sci Rep] 2019 Jun 19; Vol. 9 (1), pp. 8741. Date of Electronic Publication: 2019 Jun 19. - Publication Year :
- 2019
-
Abstract
- Mental health disorders are manifested in families, yet cannot be fully explained by classical Mendelian genetics. Changes in gene expression via epigenetics present a plausible mechanism. Anxiety often leads to avoidant behaviors which upon repetition may become habitual, maladaptive and resistant to extinction as observed in obsessive compulsive disorders (OCD). Psychophysical models of OCD propose that anxiety (amygdala) and habits (dorsolateral striatum, DLS) may be causally linked. The amygdala activates spiny projection neurons in the DLS. Repetitive amygdala terminal stimulation in the DLS elicits long term OCD-like behavior in mice associated with circuitry changes and gene methylation-mediated decrease in the activity of protein phosphatase 1 (PP1). Treatment of OCD-like grooming behavior in Slitrk5, SAPAP3, and laser-stimulated mice with one dose of RG108 (DNA methyltransferase inhibitor), lead to marked symptom improvement lasting for at least one week as well as complete reversal of anomalous changes in circuitry and PP1 gene methylation.
- Subjects :
- Animals
Disease Models, Animal
Female
Humans
Male
Mice
Tryptophan pharmacology
Compulsive Behavior drug therapy
Compulsive Behavior genetics
Compulsive Behavior metabolism
Compulsive Behavior pathology
DNA Methylation drug effects
Epigenesis, Genetic drug effects
Obsessive-Compulsive Disorder drug therapy
Obsessive-Compulsive Disorder genetics
Obsessive-Compulsive Disorder metabolism
Obsessive-Compulsive Disorder pathology
Phthalimides pharmacology
Tryptophan analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 31217515
- Full Text :
- https://doi.org/10.1038/s41598-019-45325-6