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Relationship of fibroblast growth factor 21 with subclinical atherosclerosis and cardiovascular events: Multi-Ethnic Study of Atherosclerosis.
- Source :
-
Atherosclerosis [Atherosclerosis] 2019 Aug; Vol. 287, pp. 46-53. Date of Electronic Publication: 2019 Jun 08. - Publication Year :
- 2019
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Abstract
- Background and Aims: Fibroblast growth factor 21 (FGF21) has been suggested as a novel biomarker for cardiovascular disease (CVD), especially in people with high CVD risk. However, it is not known whether FGF21 is a CVD biomarker in an initially healthy cohort. We therefore investigated the relationship of plasma FGF21 levels with measures of subclinical atherosclerosis and cardiovascular events in Multi-Ethnic Study of Atherosclerosis participants without known CVD at baseline.<br />Methods: A total of 5788 participants had plasma FGF21 levels measured at the baseline exam (2000-2002). Carotid intima-media thickness (IMT), ankle-brachial index (ABI) and coronary artery calcification (CAC) were measured at baseline. Participants were followed up for incident CVD events over a median period of 14 years.<br />Results: In cross-sectional analyses adjusting for socio-demographic variables, participants with higher FGF21 levels had higher carotid IMT, lower ABI, and higher prevalence of CAC (p < 0.001). However, these associations were not significant after simultaneously adjusting for demographic, socioeconomic and lifestyle factors, traditional CVD risk factors, and biomarkers of inflammation and hemostasis. Among 5768 patients with follow-up data, 820 developed incident CVD endpoints. Higher baseline FGF21 levels were not associated with the risk for incident CVD endpoints after adjusting for multiple confounding factors (odds ratio 1.03; 95% confidence interval, 0.94-1.12, per SD increase in ln-transformed FGF21 levels).<br />Conclusions: Although FGF21 has been suggested as a CVD biomarker for people with high CVD risk, our findings do not support a role of FGF21 as a CVD biomarker in those without a history of CVD.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Atherosclerosis diagnosis
Atherosclerosis ethnology
Biomarkers blood
Cardiovascular Diseases blood
Cardiovascular Diseases ethnology
Carotid Intima-Media Thickness
Coronary Angiography
Cross-Sectional Studies
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Prognosis
Retrospective Studies
Risk Factors
United States epidemiology
Atherosclerosis blood
Ethnicity
Fibroblast Growth Factors blood
Forecasting
Risk Assessment methods
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1484
- Volume :
- 287
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 31212234
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2019.06.898