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Cytotoxic and neuroprotective activities of constituents from Alternaria alternate, a fungal endophyte of Psidium littorale.
- Source :
-
Bioorganic chemistry [Bioorg Chem] 2019 Sep; Vol. 90, pp. 103046. Date of Electronic Publication: 2019 Jun 06. - Publication Year :
- 2019
-
Abstract
- Chemical investigation of the EtOAc extract of the plant-associated fungus Alternaria alternate in rice culture led to the isolation of a novel liphatic polyketone, alternin A (1), a new indole alkaloid (8), and a new sesquiterpene (11), together with 12 known compounds. Their structures were elucidated by the interpretation of extensive spectroscopic data, and the absolute configurations of 1-3 were established using calculations of ECD spectra, NMR data, and optical rotation values. Compound 1 possesses an unprecedented C25 liphatic polyketone skeleton. Compounds 5 and 10 exhibited potential cytotoxic activities against MCF-7 and HepG cells, and compounds 2, 7, and 9 exhibited potential neuroprotective activities in glutamate induced-PC12 injured cells.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents isolation & purification
Biological Products chemistry
Biological Products isolation & purification
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Neuroprotective Agents chemistry
Neuroprotective Agents isolation & purification
Psidium microbiology
Alternaria chemistry
Antineoplastic Agents pharmacology
Biological Products pharmacology
Endophytes chemistry
Neuroprotective Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2120
- Volume :
- 90
- Database :
- MEDLINE
- Journal :
- Bioorganic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 31212182
- Full Text :
- https://doi.org/10.1016/j.bioorg.2019.103046