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cGAS-independent STING activation in response to DNA damage.
- Source :
-
Molecular & cellular oncology [Mol Cell Oncol] 2019 Apr 19; Vol. 6 (4), pp. 1558682. Date of Electronic Publication: 2019 Apr 19 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes).
Details
- Language :
- English
- ISSN :
- 2372-3556
- Volume :
- 6
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Molecular & cellular oncology
- Publication Type :
- Academic Journal
- Accession number :
- 31211228
- Full Text :
- https://doi.org/10.1080/23723556.2018.1558682