Visible-Light-Promoted Iron-Catalyzed C(sp 2 )-C(sp 3 ) Kumada Cross-Coupling in Flow.

Authors :: Wei XJ
Abdiaj I
Sambiagio C
Li C
Zysman-Colman E
Alcázar J
Noël T
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 Sep 09; Vol. 58 (37), pp. 13030-13034. Date of Electronic Publication: 2019 Jul 11.
Publication Year :: 2019
Abstract: A continuous-flow, visible-light-promoted method has been developed to overcome the limitations of iron-catalyzed Kumada-Corriu cross-coupling reactions. A variety of strongly electron rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature in high yields and within a few minutes' residence time, considerably enhancing the applicability of this iron-catalyzed reaction. The robustness of this protocol was demonstrated on a multigram scale, thus providing the potential for future pharmaceutical application.<br /> (© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.)

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