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Genome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinoma.
- Source :
-
Nature genetics [Nat Genet] 2019 Jul; Vol. 51 (7), pp. 1131-1136. Date of Electronic Publication: 2019 Jun 17. - Publication Year :
- 2019
-
Abstract
- Epstein-Barr virus (EBV) infection is ubiquitous worldwide and is associated with multiple cancers, including nasopharyngeal carcinoma (NPC). The importance of EBV viral genomic variation in NPC development and its striking epidemic in southern China has been poorly explored. Through large-scale genome sequencing of 270 EBV isolates and two-stage association study of EBV isolates from China, we identify two non-synonymous EBV variants within BALF2 that are strongly associated with the risk of NPC (odds ratio (OR) = 8.69, P = 9.69 × 10 <superscript>-25</superscript> for SNP 162476&#95;C; OR = 6.14, P = 2.40 × 10 <superscript>-32</superscript> for SNP 163364&#95;T). The cumulative effects of these variants contribute to 83% of the overall risk of NPC in southern China. Phylogenetic analysis of the risk variants reveals a unique origin in Asia, followed by clonal expansion in NPC-endemic regions. Our results provide novel insights into the NPC endemic in southern China and also enable the identification of high-risk individuals for NPC prevention.
- Subjects :
- Case-Control Studies
China epidemiology
Epstein-Barr Virus Infections virology
Herpesvirus 4, Human classification
Herpesvirus 4, Human isolation & purification
Humans
Nasopharyngeal Carcinoma epidemiology
Nasopharyngeal Carcinoma genetics
Nasopharyngeal Neoplasms epidemiology
Nasopharyngeal Neoplasms genetics
DNA-Binding Proteins genetics
Epstein-Barr Virus Infections complications
Genome, Viral
Herpesvirus 4, Human genetics
Nasopharyngeal Carcinoma virology
Nasopharyngeal Neoplasms virology
Polymorphism, Single Nucleotide
Viral Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 51
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 31209392
- Full Text :
- https://doi.org/10.1038/s41588-019-0436-5