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Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2019 Jun 14; Vol. 24 (12). Date of Electronic Publication: 2019 Jun 14. - Publication Year :
- 2019
-
Abstract
- Cordycepin(3'-deoxyadenosine), a cytotoxic nucleoside analogue found in Cordyceps militaris , has attracted much attention due to its therapeutic potential and biological value. Cordycepin interacts with multiple medicinal targets associated with cancer, tumor, inflammation, oxidant, polyadenylation of mRNA, etc. The investigation of the medicinal drug actions supports the discovery of novel targets and the development of new drugs to enhance the therapeutic potency and reduce toxicity. Cordycepin may be of great value owing to its medicinal potential as an external drug, such as in cosmeceutical, traumatic, antalgic and muscle strain applications. In addition, the biological application of cordycepin, for example, as a ligand, has been used to uncover molecular structures. Notably, studies that investigated the metabolic mechanisms of cordycepin-producing fungi have yielded significant information related to the biosynthesis of high levels of cordycepin. Here, we summarized the medicinal targets, biological applications, cytotoxicity, delivery carriers, stability, and pros/cons of cordycepin in clinical applications, as well as described the metabolic mechanisms of cordycepin in cordycepin-producing fungi. We posit that new approaches, including single-cell analysis, have the potential to enhance medicinal potency and unravel all facets of metabolic mechanisms of cordycepin in Cordyceps militaris .<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Animals
Anti-Inflammatory Agents metabolism
Anti-Inflammatory Agents pharmacology
Anti-Inflammatory Agents therapeutic use
Antineoplastic Agents metabolism
Antineoplastic Agents pharmacology
Antineoplastic Agents therapeutic use
Antioxidants metabolism
Antioxidants pharmacology
Antioxidants therapeutic use
Clinical Studies as Topic
Deoxyadenosines therapeutic use
Drug Evaluation, Preclinical
Humans
Metabolic Networks and Pathways
Signal Transduction
Treatment Outcome
Deoxyadenosines metabolism
Deoxyadenosines pharmacology
Fungi metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 24
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 31207985
- Full Text :
- https://doi.org/10.3390/molecules24122231