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New Frontiers for Biofabrication and Bioreactor Design in Microphysiological System Development.
- Source :
-
Trends in biotechnology [Trends Biotechnol] 2019 Dec; Vol. 37 (12), pp. 1327-1343. Date of Electronic Publication: 2019 Jun 12. - Publication Year :
- 2019
-
Abstract
- Microphysiological systems (MPSs) have been proposed as an improved tool to recreate the complex biological features of the native niche with the goal of improving in vitro-in vivo extrapolation. In just over a decade, MPS technologies have progressed from single-tissue chips to multitissue plates with integrated pumps for perfusion. Concurrently, techniques for biofabrication of complex 3D constructs for regenerative medicine and 3D in vitro models have evolved into a diverse toolbox for micrometer-scale deposition of cells and cell-laden bioinks. However, as the complexity of biological models increases, experimental throughput is often compromised. This review discusses the existing disparity between MPS complexity and throughput, then examines an MPS-terminated biofabrication line to identify the hurdles and potential approaches to overcoming this disparity.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Humans
Bioreactors
Models, Biological
Tissue Engineering
Subjects
Details
- Language :
- English
- ISSN :
- 1879-3096
- Volume :
- 37
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Trends in biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 31202544
- Full Text :
- https://doi.org/10.1016/j.tibtech.2019.04.009