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Association of childhood trauma and genetic variability of CRH-BP and FKBP5 genes with suicidal behavior in bipolar patients.
- Source :
-
Journal of affective disorders [J Affect Disord] 2019 Aug 01; Vol. 255, pp. 15-22. Date of Electronic Publication: 2019 May 08. - Publication Year :
- 2019
-
Abstract
- Background: Around 8% of bipolar disorder (BD) patients die by suicide every year, accounting for the highest rate among the psychiatric population. Suicidal behavior (SB) is mediated by an intertwining system of extrinsic and intrinsic factors. Childhood trauma (CT) and gene variants of the stress-management hypothalamic-pituitary-adrenal (HPA) axis have been reported as risk factors for SB. The aim of this study was to elucidate the association of CT and HPA axis genetic variants with SB.<br />Methods: 135 BD patients were recruited for clinical assessment of CT and SB by means of the Childhood Trauma Questionnaire (CTQ) and the Columbia Suicide Severity Rating Scale (C-SSRS), respectively. A total of 28 single nucleotide polymorphisms (SNPs) from 8 HPA axis genes (POMC, NR3C2, CRH-BP, NR3C1, FKBP5, CRHR2, CRHR1, and MC2R) were genotyped.<br />Results: The analyses showed an association of total CTQ score (p = 0.003), emotional abuse (p = 0.001), sexual abuse (p = 0.005) and emotional neglect (p = 0.005) with SB. CRH-BP rs7728378-C carriers (p = 0.004; OR = 3.05), FKBP5 rs3777747-AA (p = 0.039; OR = 0.34) and FKBP5 rs2766533-GG genotypes (p = 0.001; OR = 2.93) were associated with SB although only rs2766533 survived multiple test correction. No gene-environment interaction was found.<br />Limitations: The relatively small sample size limits the statistical power to detect smaller environmental and genetic effects. Cross-sectional data collection in psychometric assessments can yield biased data.<br />Conclusions: The present study characterizes novel SB risk factors and replicates previous findings in BD patients. CT and variability in CRH-BP and FKBP5 genes should be further studied for a better understanding of SB and ultimately help in suicide prevention.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Child
Cross-Sectional Studies
Female
Gene-Environment Interaction
Genotype
Humans
Hypothalamo-Hypophyseal System
Male
Middle Aged
Pituitary-Adrenal System
Polymorphism, Single Nucleotide
Risk Factors
Bipolar Disorder genetics
Bipolar Disorder psychology
Carrier Proteins genetics
Child Abuse psychology
Suicidal Ideation
Suicide
Tacrolimus Binding Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2517
- Volume :
- 255
- Database :
- MEDLINE
- Journal :
- Journal of affective disorders
- Publication Type :
- Academic Journal
- Accession number :
- 31195252
- Full Text :
- https://doi.org/10.1016/j.jad.2019.05.014