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Associations of depression severity with heart rate and heart rate variability in young adults across normative and clinical populations.
- Source :
-
International journal of psychophysiology : official journal of the International Organization of Psychophysiology [Int J Psychophysiol] 2019 Aug; Vol. 142, pp. 57-65. Date of Electronic Publication: 2019 Jun 10. - Publication Year :
- 2019
-
Abstract
- Limitations of current depression treatments may arise from a lack of knowledge about unique psychophysiological processes that contribute to depression across the full range of presentations. This study examined how individual variations in heart rate (HR) and heart rate variability (HRV) are related to depressive symptoms across normative and clinical populations in 152 young adults (aged 18-35 years). Moderating effects of sex and antidepressant medication status were considered. Electrocardiogram data were collected during "vanilla" baseline and in response to positive and negative emotional cues. Linear regressions and repeated-measures mixed models were used to assess the relationships between Beck Depression Inventory-II (BDI-II) scores, sex, antidepressant use, and cardiovascular outcomes. Baseline models yielded significant main effects of BDI-II and sex on HR and significant interactions between antidepressant medication status and BDI-II on HRV outcomes. The main effects of BDI-II and sex on HR were no longer significant after controlling for cardiorespiratory fitness. Participants who denied current antidepressant use (n = 137) exhibited a negative association and participants who endorsed current antidepressant (n = 15) use exhibited a positive association between BDI-II scores and HRV. Emotional reactivity models were largely non-significant with the exception of a significant main effect of antidepressant medication status on high-frequency HRV reactivity. Results indicated antidepressant medication use may moderate the relationship between depression severity and cardiovascular functioning, but this requires replication given the modest proportion of medicated individuals in this study. Overall, findings suggest cardiovascular processes and cardiorespiratory fitness are linked to depression symptomatology and may be important to consider in depression treatment.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Adult
Antidepressive Agents pharmacology
Autonomic Nervous System drug effects
Depression drug therapy
Depressive Disorder drug therapy
Electrocardiography
Emotional Regulation drug effects
Female
Heart Rate drug effects
Humans
Male
Severity of Illness Index
Sex Factors
Young Adult
Autonomic Nervous System physiopathology
Depression physiopathology
Depressive Disorder physiopathology
Emotional Regulation physiology
Heart Rate physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7697
- Volume :
- 142
- Database :
- MEDLINE
- Journal :
- International journal of psychophysiology : official journal of the International Organization of Psychophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 31195066
- Full Text :
- https://doi.org/10.1016/j.ijpsycho.2019.06.005