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Recombinant cystatins in plants.
- Source :
-
Biochimie [Biochimie] 2019 Nov; Vol. 166, pp. 184-193. Date of Electronic Publication: 2019 Jun 11. - Publication Year :
- 2019
-
Abstract
- Dozens of studies have assessed the practical value of plant cystatins as ectopic inhibitors of Cys proteases in biological systems. The potential of these proteins in crop protection to control herbivorous pests and pathogens has been documented extensively over the past 25 years. Their usefulness to regulate endogenous Cys proteases in planta has also been considered recently, notably to implement novel traits of agronomic relevance in crops or to generate protease activity-depleted environments in plants or plant cells used as bioreactors for recombinant proteins. After a brief update on the basic structural characteristics of plant cystatins, we summarize recent advances on the use of these proteins in plant biotechnology. Attention is also paid to the molecular improvement of their structural properties for the improvement of their protease inhibitory effects or the fine-tuning of their biological target range.<br /> (Copyright © 2019 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.)
- Subjects :
- Biotechnology
Cysteine Proteases metabolism
Pest Control, Biological
Protein Engineering
Recombinant Proteins chemistry
Recombinant Proteins pharmacology
Cystatins chemistry
Cystatins physiology
Cysteine Proteinase Inhibitors chemistry
Cysteine Proteinase Inhibitors pharmacology
Plant Proteins chemistry
Plant Proteins physiology
Plants metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1638-6183
- Volume :
- 166
- Database :
- MEDLINE
- Journal :
- Biochimie
- Publication Type :
- Academic Journal
- Accession number :
- 31194996
- Full Text :
- https://doi.org/10.1016/j.biochi.2019.06.006