[Observation on therapeutic effect of " Tiaoren Tongdu acupuncture" on premature ovarian insufficiency of kidney deficiency].

Objective: To observe the clinical efficacy of " Tiaoren Tongdu acupuncture" and oral estradiol and dydrogesterone tablets (femoston) on premature ovarian insufficiency of kidney deficiency.
Methods: A total of 50 patients with premature ovarian insufficiency of kidney deficiency were randomized into an observation group and a control group, 25 cases in each one.In the observation group, " Tiaoren Tongdu acupuncture" was applied at Baihui (GV 20), Zhongwan (CV 12), Guanyuan (CV 4), Qihai (CV 6), Zhongji (CV 3), Yaoyangguan (GV 3), Yaoshu (GV 2), Mingmen (GV 4), etc. once every 2 days, 1 month as a course. In the control group, femoston was prescribed for oral administration, one tablet per time, once a day, 1 month as a course. Both of the two groups were given consecutive treatment for 3 courses. Before and after treatment, the clinical symptoms, menstrual improvement as well as the changes of estradiol (E ₂ ), luteotrophic hormone (LH) and follicle-stimulating hormone (FSH) in serum were observed in the two groups.
Results: After treatment, the clinical symptoms and menstrual conditions were improved ( P <0.01), the levels of FSH and LH were significantly reduced ( P <0.01), and the levels of E ₂ were significantly increased in the two groups ( P <0.01). There were no significant difference in menstrual improvement rate and menstrual improvement time between the observation group and the control group ( P <0.05), the recurrence rate of menopause and clinical symptom score improvement in the observation group were superior to the control group ( P <0.05). In the observation group, the level of E ₂ in serum was lower and the levels of FSH and LH in serum were significantly lower than those in the control group ( P <0.05, P <0.01). In the observation group, the rate of adverse reaction was 4.0% (1/25), which was lower than 36.0% (9/25) in the control group ( P <0.05).
Conclusion: " Tiaoren Tongdu acupuncture" has better therapeutic effect for premature ovarian insufficiency of kidney deficiency. It is superior to femoston in improving clinical symptoms and recurrence rate of menopause as well as reducing the levels of FSH and LH.