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Reciprocal Multifaceted Interaction Between HDL (High-Density Lipoprotein) and Myocardial Infarction.
- Source :
-
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2019 Aug; Vol. 39 (8), pp. 1550-1564. Date of Electronic Publication: 2019 Jun 13. - Publication Year :
- 2019
-
Abstract
- Despite decades of therapeutic advances, myocardial infarction remains a leading cause of death worldwide. Recent studies have identified HDLs (high-density lipoproteins) as a potential candidate for mitigating coronary ischemia/reperfusion injury via a broad spectrum of signaling pathways. HDL ligands, such as S1P (sphingosine-1-phosphate), Apo (apolipoprotein) A-I, clusterin, and miRNA, may influence the opening of the mitochondrial channel, insulin sensitivity, and production of vascular autacoids, such as NO, prostacyclin, and endothelin-1. In parallel, antioxidant activity and sequestration of oxidized molecules provided by HDL can attenuate the oxidative stress that triggers ischemia/reperfusion. Nevertheless, during myocardial infarction, oxidation and the capture of oxidized and proinflammatory molecules generate large phenotypic and functional changes in HDL, potentially limiting its beneficial properties. In this review, new findings from cellular and animal models, as well as from clinical studies, will be discussed to describe the cardioprotective benefits of HDL on myocardial infarction. Furthermore, mechanisms by which HDL modulates cardiac function and potential strategies to mitigate postmyocardial infarction risk damage by HDL will be detailed throughout the review.
- Subjects :
- Animals
Cholesterol metabolism
Endothelial Cells physiology
Glucose metabolism
Homeostasis
Humans
Lipoproteins, HDL blood
Lysophospholipids physiology
Oxidative Stress
Signal Transduction physiology
Sphingosine analogs & derivatives
Sphingosine physiology
Lipoproteins, HDL physiology
Myocardial Infarction prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4636
- Volume :
- 39
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Arteriosclerosis, thrombosis, and vascular biology
- Publication Type :
- Academic Journal
- Accession number :
- 31189429
- Full Text :
- https://doi.org/10.1161/ATVBAHA.119.312880