Back to Search
Start Over
Robust Control of a Brain-Persisting Parasite through MHC I Presentation by Infected Neurons.
- Source :
-
Cell reports [Cell Rep] 2019 Jun 11; Vol. 27 (11), pp. 3254-3268.e8. - Publication Year :
- 2019
-
Abstract
- Control of CNS pathogens by CD8 T cells is key to avoid fatal neuroinflammation. Yet, the modalities of MHC I presentation in the brain are poorly understood. Here, we analyze the antigen presentation mechanisms underlying CD8 T cell-mediated control of the Toxoplasma gondii parasite in the CNS. We show that MHC I presentation of an efficiently processed model antigen (GRA6-OVA), even when not expressed in the bradyzoite stage, reduces cyst burden and dampens encephalitis in C57BL/6 mice. Antigen presentation assays with infected primary neurons reveal a correlation between lower MHC I presentation of tachyzoite antigens by neurons and poor parasite control in vivo. Using conditional MHC I-deficient mice, we find that neuronal MHC I presentation is required for robust restriction of T. gondii in the CNS during chronic phase, showing the importance of MHC I presentation by CNS neurons in the control of a prevalent brain pathogen.<br /> (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Antigens, Protozoan immunology
Brain cytology
Brain parasitology
Cell Line
Cells, Cultured
Histocompatibility Antigens Class I genetics
Humans
Male
Mice
Mice, Inbred C57BL
Neurons immunology
Neurons parasitology
Protozoan Proteins immunology
Toxoplasma immunology
Toxoplasma pathogenicity
Antibodies, Protozoan immunology
Brain immunology
Histocompatibility Antigens Class I immunology
Toxoplasmosis, Cerebral immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2211-1247
- Volume :
- 27
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Cell reports
- Publication Type :
- Academic Journal
- Accession number :
- 31189109
- Full Text :
- https://doi.org/10.1016/j.celrep.2019.05.051