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Homocysteine Serum Levels as Prognostic Marker of Hepatocellular Carcinoma with Portal Vein Thrombosis.
- Source :
-
Current molecular medicine [Curr Mol Med] 2019; Vol. 19 (7), pp. 532-538. - Publication Year :
- 2019
-
Abstract
- Background: Portal vein thrombosis (PVT) is a common complication of endstage hepatocellular carcinoma (HCC). The aim of our study was to evaluate the role of Homocysteine (Hcy) in HCC patient with PVT. Hcy is a sulphur amino-acid involved in two pathways, trans-sulphuration and remethylation, that involve vitamins B6, B12 and folates.<br />Methods: We recruited 54 patients with HCC and PVT, 60 patients with HCC and without PVT and 60 control subjects. We measured serum levels of Hcy, folate, vitamins B6 and B12.<br />Results: The comparison between HCC patients with PVT versus HCC without PVT was shown that mean values of Hcy were 6.4 nmol/L (p<0.0073) higher, LDL cholesterol were 4.8 mg/dl (p<0.0079) lower, vitamin B6 were 4.6 nmol/L(p=0.0544) lower, vitamins B 12 were 22.1 pg/ml (p=0.0001) lower.<br />Conclusion: High serum levels of Hcy are an established thrombotic risk factor in the general population. We found significantly higher levels of Hcy in HCC patients with PVT versus both HCC patients without PVT and controls.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Subjects :
- Adult
Aged
Budd-Chiari Syndrome blood
Budd-Chiari Syndrome genetics
Budd-Chiari Syndrome pathology
Carcinoma, Hepatocellular genetics
Carcinoma, Hepatocellular pathology
Cholesterol, LDL blood
Female
Folic Acid genetics
Folic Acid metabolism
Humans
Liver Neoplasms genetics
Liver Neoplasms pathology
Male
Middle Aged
Portal Vein metabolism
Portal Vein pathology
Prognosis
Vitamin B 12 genetics
Vitamin B 12 metabolism
Vitamin B 6 genetics
Vitamin B 6 metabolism
Biomarkers, Tumor blood
Carcinoma, Hepatocellular blood
Homocysteine blood
Liver Neoplasms blood
Subjects
Details
- Language :
- English
- ISSN :
- 1875-5666
- Volume :
- 19
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Current molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31187711
- Full Text :
- https://doi.org/10.2174/1566524019666190610120416