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Four Yellow Monoterpenoid Quinoline Alkaloids from the Stem of Tabernaemontana bovina.
- Source :
-
Organic letters [Org Lett] 2019 Jun 21; Vol. 21 (12), pp. 4554-4558. Date of Electronic Publication: 2019 Jun 10. - Publication Year :
- 2019
-
Abstract
- Four unprecedented yellow alkaloids named as taberbovines A-D (1-4) were isolated from stems of Tabernaemontana bovina Lour. Their structures were elucidated by the comprehensive spectroscopic data, computational chemistry, and X-ray crystal diffraction. Alkaloids 1-4 possessed a unique 6/6/5/6/5 ring system and were assigned to monoterpenoid quinolines. Biosynthetically, the isolated alkaloids may be derived from Aspidosperma-type alkaloid by oxidation and rearrangements. Taberbovines A-D exhibited the good inhibitory activities of formation NO in LPS induced RAW264.7 macrophages.
- Subjects :
- Alkaloids chemistry
Alkaloids isolation & purification
Animals
Crystallography, X-Ray
Lipopolysaccharides antagonists & inhibitors
Lipopolysaccharides pharmacology
Macrophages drug effects
Macrophages metabolism
Mice
Models, Molecular
Molecular Structure
Nitric Oxide biosynthesis
Quinolines chemistry
Quinolines isolation & purification
RAW 264.7 Cells
Alkaloids pharmacology
Nitric Oxide antagonists & inhibitors
Quinolines pharmacology
Tabernaemontana chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 21
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 31179705
- Full Text :
- https://doi.org/10.1021/acs.orglett.9b01453