Six new monacolin analogs from red yeast rice.

Authors :: Liu BY
Xu F
Bai J
Yan DJ
Zhang L
Zhang D
Hu YC
Source :: Chinese journal of natural medicines [Chin J Nat Med] 2019 May 20; Vol. 17 (5), pp. 394-400.
Publication Year :: 2019
Abstract: Six novel monacolin analogs, monacolins V <subscript>1</subscript> -V <subscript>6</subscript> (1-6), together with seven known ones (7-13), were isolated from the ethyl acetate extract of red yeast rice. Their structures and absolute configurations were determined by spectroscopic methods, especially 2D NMR ( <superscript>1</superscript> H- <superscript>1</superscript> HCOSY, HSQC, HMBC, and NOESY/ROESY) and CD spectroscopic analyses as well as chemical derivation. Monacolins V <subscript>2</subscript> (2) and V <subscript>3</subscript> (3) represent the first examples of monacolins with 3-hydroxybutyrate substitute. The anti-inflammatory inhibitory activities against the lipopolysaccharide (LPS) induced NO production in BV-2 cells as well as antioxidant activities against rat liver microsomal lipid peroxidation were evaluated.<br /> (Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.)