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Dietary yeast influences ethanol sedation in Drosophila via serotonergic neuron function.
- Source :
-
Addiction biology [Addict Biol] 2020 Jul; Vol. 25 (4), pp. e12779. Date of Electronic Publication: 2019 Jun 06. - Publication Year :
- 2020
-
Abstract
- Abuse of alcohol is a major clinical problem with far-reaching health consequences. Understanding the environmental and genetic factors that contribute to alcohol-related behaviors is a potential gateway for developing novel therapeutic approaches for patients that abuse the drug. To this end, we have used Drosophila melanogaster as a model to investigate the effect of diet, an environmental factor, on ethanol sedation. Providing flies with diets high in yeast, a routinely used component of fly media, increased their resistance to ethanol sedation. The yeast-induced resistance to ethanol sedation occurred in several different genetic backgrounds, was observed in males and females, was elicited by yeast from different sources, was readily reversible, and was associated with increased nutrient intake as well as decreased internal ethanol levels. Inhibition of serotonergic neuron function using multiple independent genetic manipulations blocked the effect of yeast supplementation on ethanol sedation, nutrient intake, and internal ethanol levels. Our results demonstrate that yeast is a critical dietary component that influences ethanol sedation in flies and that serotonergic signaling is required for the effect of dietary yeast on nutrient intake, ethanol uptake/elimination, and ethanol sedation. Our studies establish the fly as a model for diet-induced changes in ethanol sedation and raise the possibility that serotonin might mediate the effect of diet on alcohol-related behavior in other species.<br /> (© 2019 Society for the Study of Addiction.)
- Subjects :
- Animals
Drosophila melanogaster
Female
Hypnotics and Sedatives pharmacology
Male
Saccharomyces cerevisiae
Serotonergic Neurons metabolism
Serotonin metabolism
Behavior, Animal drug effects
Central Nervous System Depressants pharmacology
Diet
Ethanol pharmacology
Serotonergic Neurons drug effects
Yeast, Dried
Subjects
Details
- Language :
- English
- ISSN :
- 1369-1600
- Volume :
- 25
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Addiction biology
- Publication Type :
- Academic Journal
- Accession number :
- 31169340
- Full Text :
- https://doi.org/10.1111/adb.12779