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Association Analysis: Fetal Alcohol Spectrum Disorder and Hypertension Status in Children and Adolescents.
- Source :
-
Alcoholism, clinical and experimental research [Alcohol Clin Exp Res] 2019 Aug; Vol. 43 (8), pp. 1727-1733. Date of Electronic Publication: 2019 Jun 24. - Publication Year :
- 2019
-
Abstract
- Background: This study examined the relationship between prenatal exposure to alcohol, manifested through fetal alcohol syndrome (FAS) and pFAS, and hypertension in children and adolescents.<br />Methods: This study was designed to analyze the association between fetal alcohol spectrum disorders (FASD) Status and hypertension status. FAS/pFAS-diagnosed respondents (n = 125) were collected from a FASD Clinical database in Atlanta, Georgia. Non-FAS/pFAS respondents (n = 500) were taken from the National Health and Nutrition Examination Survey (NHANES). Chi-square analyses were used to examine the extent to which FASD status, sex, race/ethnicity, medication use, and obesity status each related to hypertension status. A logistic regression was performed analyzing the relationship between FASD status (y/n: independent) and hypertension status (y/n: dependent) while controlling for age, sex, race/ethnicity, medication use, and obesity status.<br />Results: Univariate relationships between hypertension status and FASD status (OR = 8.46, p < 0.001), medication use (OR = 3.25, p < 0.001), and obesity status (OR = 3.03, p = 0.02) proved to be statistically significant (p < 0.05). FASD status significantly predicted hypertension status (β = 2.31, OR = 10.06, p < 0.001) after accounting for age, sex, race/ethnicity, medication use, and obesity status.<br />Conclusions: The major findings of this study suggest a significant relationship between FASD and hypertension in youth. Race/ethnicity and obesity also proved important in predicting hypertensive blood pressure readings independent of FASD diagnosis. Further research is needed to isolate prenatal alcohol exposure (PAE) as a factor promoting increased hypertension and to assess the risk for hypertension in alcohol-affected adults.<br /> (© 2019 by the Research Society on Alcoholism.)
- Subjects :
- Adolescent
Age Factors
Child
Comorbidity
Databases, Factual statistics & numerical data
Female
Georgia epidemiology
Humans
Male
Nutrition Surveys statistics & numerical data
Pregnancy
Prenatal Exposure Delayed Effects
Risk Factors
Sex Factors
Alcohol Drinking adverse effects
Cardiovascular Diseases epidemiology
Fetal Alcohol Spectrum Disorders epidemiology
Hypertension epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1530-0277
- Volume :
- 43
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Alcoholism, clinical and experimental research
- Publication Type :
- Academic Journal
- Accession number :
- 31166027
- Full Text :
- https://doi.org/10.1111/acer.14121