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Soluble Forms of the Receptor for Advanced Glycation Endproducts (RAGE) in Periodontitis.
- Source :
-
Scientific reports [Sci Rep] 2019 Jun 03; Vol. 9 (1), pp. 8170. Date of Electronic Publication: 2019 Jun 03. - Publication Year :
- 2019
-
Abstract
- The receptor for advanced glycation endproducts (RAGE) is critically involved in the pathobiology of chronic inflammatory diseases. Soluble forms of RAGE have been proposed as biomarkers of severity in inflammatory and metabolic conditions, and in monitoring therapeutic responses. The aim of the present study was to determine circulating levels of the soluble forms of RAGE in periodontitis and to evaluate the expression of cell-bound, full-length RAGE and its antagonist AGER1 locally, in gingival tissues. Periodontitis patients and periodontally healthy, sex- and age-matched controls (50 per group) were included. Serum levels of total soluble RAGE and cleaved RAGE (cRAGE) were significantly lower in periodontitis patients. Levels of the endogenous secretory esRAGE were similar in the two groups. cRAGE remained significantly lower in the periodontitis group following multiple adjustments, and had a statistically significant inverse correlation with body mass index and all periodontal parameters. In periodontitis patients, gene expression of full-length RAGE and of AGER1 were significantly higher in periodontitis-affected gingival tissues compared to healthy gingiva. Soluble forms of RAGE, particularly cRAGE, may serve as biomarkers for the presence and severity/extent of periodontitis, and may be implicated in its pathogenesis and its role as a systemic inflammatory stressor.
- Subjects :
- Adult
Antigens, Neoplasm blood
Biomarkers blood
Body Mass Index
Female
Gingiva metabolism
Gingiva pathology
Humans
Inflammation blood
Inflammation pathology
Male
Middle Aged
Mitogen-Activated Protein Kinases blood
Periodontitis blood
Periodontitis pathology
Solubility
Antigens, Neoplasm genetics
Glycation End Products, Advanced genetics
Inflammation genetics
Mitogen-Activated Protein Kinases genetics
Periodontitis genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 31160611
- Full Text :
- https://doi.org/10.1038/s41598-019-44608-2