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GLP-1 Receptor Agonists and Kidney Protection.
- Source :
-
Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2019 May 31; Vol. 55 (6). Date of Electronic Publication: 2019 May 31. - Publication Year :
- 2019
-
Abstract
- Type 2 diabetes mellitus (T2DM) is the leading cause of chronic kidney disease (CKD). Diabetic nephropathy (DN) is determined by specific pathological structural and functional alterations of the kidneys in patients with diabetes, and its clinical manifestations are albuminuria and decline of glomerular filtration rate (GFR). Apart from renin-angiotensin-aldosterone system (RAAS) inhibitors, no other drugs are currently available as therapy for diabetic kidney disease (DKD). Glucagon-like peptide-1 receptor (GLP-1R) agonists are a new class of anti-hyperglycemic drugs which have been demonstrated to prevent the onset of macroalbuminuria and reduce the decline of GFR in diabetic patients. These drugs may exert their beneficial actions on the kidneys through blood glucose- and blood pressure (BP)-lowering effects, reduction of insulin levels and weight loss. Clinical benefits of GLP-1R agonists were acknowledged due to data from large randomized phase III clinical trials conducted to assess their cardiovascular(CV) safety. These drugs improved renal biomarkers in placebo-controlled clinical studies, with effects supposed to be independent of the actions on glycemic control. In this review, we will focus on the actions of GLP-1R agonists on glucose metabolism and kidney physiology, and evaluate direct and indirect mechanisms through which these drugs may confer renal protection.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 genetics
Diabetic Nephropathies complications
Diabetic Nephropathies drug therapy
Glucagon-Like Peptide-1 Receptor therapeutic use
Humans
Kidney physiopathology
Protective Agents pharmacology
Protective Agents therapeutic use
Glucagon-Like Peptide-1 Receptor agonists
Kidney drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1648-9144
- Volume :
- 55
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Medicina (Kaunas, Lithuania)
- Publication Type :
- Academic Journal
- Accession number :
- 31159279
- Full Text :
- https://doi.org/10.3390/medicina55060233