Polymeric nanoparticles responsive to intracellular ROS for anticancer drug delivery.

Authors :: Xu L
Zhao M
Gao W
Yang Y
Zhang J
Pu Y
He B
Source :: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2019 Sep 01; Vol. 181, pp. 252-260. Date of Electronic Publication: 2019 May 25.
Publication Year :: 2019
Abstract: Thioketal and thioether are moieties used to fabricate reactive oxygen species (ROS)-responsive polymers for drug delivery. In this paper, three amphiphilic copolymers of mPEG-poly(ester-thioether), mPEG-poly(thioketal-ester) and mPEG-poly(thioketal-ester-thioether) were synthesized. The ROS-responsive behaviors of the three copolymers nanoparticles as drug carriers were investigated. The ROS-sensitivity was demonstrated by NMR, DLS, and SEM. mPEG-poly(ester-thioether) nanoparticles exhibited the fastest drug release rate, which possessed the best ROS sensitivity. The in vitro anticancer activity of the DOX-loaded nanoparticles was studied, the results revealed that the mPEG-poly(ester-thioether) nanoparticles showed the most efficient anticancer activity. Notably, all the three ROS-responsive copolymers nanoparticles showed enhanced cellular uptake and anticancer efficacy comparing to the control mPEG-b-PCL nanoparticles.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)

Subjects :: Antibiotics, Antineoplastic chemical synthesis
Antibiotics, Antineoplastic chemistry
Cell Line, Tumor
Cell Survival drug effects
Doxorubicin chemical synthesis
Doxorubicin chemistry
Drug Carriers chemistry
Drug Liberation
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Micelles
Molecular Structure
Antibiotics, Antineoplastic pharmacology
Doxorubicin pharmacology
Drug Delivery Systems
Nanoparticles chemistry
Polymers chemistry
Reactive Oxygen Species metabolism

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