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Enhanced organic-inorganic heterojunction of polypyrrole@Bi 2 WO 6 : Fabrication and application for sensitive photoelectrochemical immunoassay of creatine kinase-MB.
- Source :
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Biosensors & bioelectronics [Biosens Bioelectron] 2019 Sep 01; Vol. 140, pp. 111349. Date of Electronic Publication: 2019 May 25. - Publication Year :
- 2019
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Abstract
- In this report, enhanced organic-inorganic heterojunction of polypyrrole@Bi <subscript>2</subscript> WO <subscript>6</subscript> was fabricated and applied for sensitive photoelectrochemical (PEC) immunoassay of creatine kinase-MB (CK-MB). Specifically, heterostructured polypyrrole@Bi <subscript>2</subscript> WO <subscript>6</subscript> photoelectrode was prepared and sandwich immunorecognition were integrated for the CK-MB immunoassay. In the detection, with the aid of alkaline phosphate (ALP)-induced biocatalytic precipitation (BCP), the precipitation-dependent suppression of the photocurrent can be recorded due to the impediment of the interfacial mass and electron transfer. On the basis of target-controlled BCP formation, a novel PEC immunoassay could be developed for the sensitive and specific CK-MB detection. This work manifested the great potential of polypyrrole@Bi <subscript>2</subscript> WO <subscript>6</subscript> heterojunction as a novel platform for PEC bioanalysis development and also a PEC method for CK-MB detection. This work is expected to stimulate more interest in the design and implementation of numerous other organic-inorganic heterojunction for advanced PEC bioanalysis development.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-4235
- Volume :
- 140
- Database :
- MEDLINE
- Journal :
- Biosensors & bioelectronics
- Publication Type :
- Academic Journal
- Accession number :
- 31150983
- Full Text :
- https://doi.org/10.1016/j.bios.2019.111349