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Does donor-recipient age difference matter in outcome of heart transplantation?
- Source :
-
Clinical transplantation [Clin Transplant] 2019 Jul; Vol. 33 (7), pp. e13593. Date of Electronic Publication: 2019 Jun 19. - Publication Year :
- 2019
-
Abstract
- Objective: Potential interactions between donor-recipient age difference and outcomes after heart transplantation are not well known. We thus aimed to study the impact of donor-recipient age difference on heart transplantation outcomes.<br />Methods: Between 1995 and 2017, we assessed 234 heart transplantation patients. Based on donor-recipient age difference histogram, we stratified these patients into three groups: older donors (donor-recipient difference > 0; n = 48), younger donors (donor-recipient difference 0 to -20 years; n = 82), and much younger donors (donor-recipient difference <-20 years; n = 104).<br />Results: The baseline metabolic risk profile of the recipients was significantly higher for the much younger donor group compared with the younger and older groups, including hypertension (52% vs 33% vs 25%, P = 0.002), dyslipidemia (51% vs 51% vs 29%, P = 0.027), diabetes (30% vs 16% vs 17%, P = 0.044), and smoking history (53% vs 46% vs 29%, P = 0.024), respectively. There were no significant differences between the groups in long-term survival, cardiac allograft vasculopathy, or rejection-free survival in unadjusted and adjusted analyses. In the much younger donor group, gender matching was associated with a lower incidence of primary graft dysfunction (37% vs 58% P = 0.05).<br />Conclusions: Donor-recipient age difference does not significantly impact long-term heart transplantation outcomes.<br /> (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Female
Follow-Up Studies
Graft Rejection etiology
Graft Survival
Heart Transplantation adverse effects
Humans
Male
Middle Aged
Postoperative Complications etiology
Primary Graft Dysfunction etiology
Prognosis
Retrospective Studies
Risk Factors
Survival Rate
Tissue Donors statistics & numerical data
Young Adult
Graft Rejection mortality
Heart Transplantation mortality
Postoperative Complications mortality
Primary Graft Dysfunction mortality
Tissue Donors supply & distribution
Transplant Recipients statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1399-0012
- Volume :
- 33
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Clinical transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 31148258
- Full Text :
- https://doi.org/10.1111/ctr.13593