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Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy.
- Source :
-
Nature medicine [Nat Med] 2019 Jun; Vol. 25 (6), pp. 1001-1011. Date of Electronic Publication: 2019 May 29. - Publication Year :
- 2019
-
Abstract
- The microbiome of the female reproductive tract has implications for women's reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant women of African, Hispanic or European ancestry case-matched for race, gestational age and household income; and a longitudinally sampled cohort of 90 pregnant women of African or non-African ancestry. In these women, the vaginal microbiome shifted during pregnancy toward Lactobacillus-dominated profiles at the expense of taxa often associated with vaginal dysbiosis. The shifts occurred early in pregnancy, followed predictable patterns, were associated with simplification of the metabolic capacity of the microbiome and were significant only in women of African or Hispanic ancestry. Both genomic and environmental factors are likely contributors to these trends, with socioeconomic status as a likely environmental influence.
- Subjects :
- Adult
Black or African American
Biodiversity
Cohort Studies
Cross-Sectional Studies
Female
Hispanic or Latino
Host Microbial Interactions genetics
Host Microbial Interactions physiology
Humans
Social Class
White People
Microbiota genetics
Microbiota physiology
Pregnancy physiology
Vagina microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1546-170X
- Volume :
- 25
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nature medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31142850
- Full Text :
- https://doi.org/10.1038/s41591-019-0465-8