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Comparative anatomy of the mouse and human ankle joint using Micro-CT: Utility of a mouse model to study human ankle sprains.
- Source :
-
Mathematical biosciences and engineering : MBE [Math Biosci Eng] 2019 Apr 10; Vol. 16 (4), pp. 2959-2972. - Publication Year :
- 2019
-
Abstract
- The use of mouse models as a tool to study ankle sprain requires a basic understanding of the similarities and differences between human and mouse ankle joint anatomy. However, few studies have been conducted that address the merits and drawbacks of these differences in the functioning of joints. Twenty hindfoot specimens were obtained from 10 male C57BL/6J mice and scanned using micro-CT. The foot and ankle skeletal structures were reconstructed in three dimensions. Morphological parameters were then measured using a plane projection method and normalized data were compared with those of human ankles. There was no significant difference in the malleolar width, maximal tibial thickness, tibial arc length, trochlea tali arc length or trochlea tali width of the mouse specimens compared with the human model. However, a groove was observed on the talar dome in the mouse specimens which was not observed in humans, the talar dome being more symmetric. The mouse ankle was to a large extent able to mimic the mechanism of a human ankle and so a mouse model could be appropriate for expanding our understanding of ankle biomechanics in general. However, the structural differences in the talar dome in the mouse and human should not be ignored. Although there are some differences in the mouse and human ankle that cannot be ignored, compared to other animals, the human ankle is more similar to that of the mouse.
- Subjects :
- Animals
Ankle Injuries pathology
Biomechanical Phenomena
Disease Models, Animal
Hindlimb anatomy & histology
Hindlimb diagnostic imaging
Hindlimb injuries
Humans
Male
Mathematical Concepts
Mice
Mice, Inbred C57BL
Models, Anatomic
Species Specificity
Talus anatomy & histology
Talus diagnostic imaging
Talus injuries
Tarsal Joints anatomy & histology
Tarsal Joints diagnostic imaging
Tarsal Joints injuries
X-Ray Microtomography
Ankle Injuries diagnostic imaging
Ankle Joint anatomy & histology
Ankle Joint diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1551-0018
- Volume :
- 16
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Mathematical biosciences and engineering : MBE
- Publication Type :
- Academic Journal
- Accession number :
- 31137245
- Full Text :
- https://doi.org/10.3934/mbe.2019146